RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
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چکیده
منابع مشابه
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3). How KDM4D is recruited to chromatin and recognizes its histone substrates remains unknown. Here, we show that KDM4D binds RNA independently of its demethylase activity. We mapped two non-canonical RNA binding domains: the first is within the N-terminal spanning amino acids 115...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2014
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gku1021